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![]( "Buchcover ISBN 9781118354315")
„This book serves as an invaluable source of informationfor the formulation scientist, the preclinical, translational orclinical pharmacokineticist, as well as the modeling and simulationscientist.“ (ChemMedChem, 1 April 2013)
Biopharmaceutics Modeling and Simulations
Theory, Practice, Methods, and Applications
von Kiyohiko SuganoA comprehensive introduction to using modeling and simulationprograms in drug discovery and development
Biopharmaceutical modeling has become integral to the design anddevelopment of new drugs. Influencing key aspects of thedevelopment process, including drug substance design, formulationdesign, and toxicological exposure assessment, biopharmaceuticalmodeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available softwareprograms for drug modeling, there has not been a single resourceguiding pharmaceutical professionals to the actual tools andpractices needed to design and test safe drugs.
A guide to the basics of modeling and simulation programs, Biopharmaceutics Modeling and Simulations offerspharmaceutical scientists the keys to understanding how they workand are applied in creating drugs with desired medicinalproperties. Beginning with a focus on the oral absorption of drugs, the book discusses:
* The central dogma of oral drug absorption (the interplay ofdissolution, solubility, and permeability of a drug), which formsthe basis of the biopharmaceutical classification system (BCS)
* The concept of drug concentration
* How to simulate key drug absorption processes
* The physiological and drug property data used forbiopharmaceutical modeling
* Reliable practices for reporting results
With over 200 figures and illustrations and a peerlessexamination of all the key aspects of drug research--includingrunning and interpreting models, validation, and compound andformulation selection--this reference seamlessly bringstogether the proven practical approaches essential to developingthe safe and effective medicines of tomorrow.
Biopharmaceutical modeling has become integral to the design anddevelopment of new drugs. Influencing key aspects of thedevelopment process, including drug substance design, formulationdesign, and toxicological exposure assessment, biopharmaceuticalmodeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available softwareprograms for drug modeling, there has not been a single resourceguiding pharmaceutical professionals to the actual tools andpractices needed to design and test safe drugs.
A guide to the basics of modeling and simulation programs, Biopharmaceutics Modeling and Simulations offerspharmaceutical scientists the keys to understanding how they workand are applied in creating drugs with desired medicinalproperties. Beginning with a focus on the oral absorption of drugs, the book discusses:
* The central dogma of oral drug absorption (the interplay ofdissolution, solubility, and permeability of a drug), which formsthe basis of the biopharmaceutical classification system (BCS)
* The concept of drug concentration
* How to simulate key drug absorption processes
* The physiological and drug property data used forbiopharmaceutical modeling
* Reliable practices for reporting results
With over 200 figures and illustrations and a peerlessexamination of all the key aspects of drug research--includingrunning and interpreting models, validation, and compound andformulation selection--this reference seamlessly bringstogether the proven practical approaches essential to developingthe safe and effective medicines of tomorrow.
