Principles of Receptor Research

Inhaltsverzeichnis

• 1 Blood-Brain Barrier: Techniques for the Intracerebral Administration of Drugs.
• 1. Introduction.
• 2. Characteristics of the Blood-Brain Barrier.
• 3. Bypassing the Blood-Brain Barrier: Principles.
• 4. Pharmacological Approach to the Internal or External Surface of the Brain.
• 5. Drugs Administered to the Brain Parenchyma.
• 6. Concluding Comment.
• 7. References.
• 2 Microiontophoretic Application of Drugs onto Single Neurons.
• 2. Basic Principles.
• 3. Dispersal of Iontophoretically Applied Substances Within the Brain.
• 4. Conclusions.
• 5. References.
• 3 Electrical Recording of Brain Activity: The EEG and Its Value in Assessing Drug Effects.
• 2. Selection of Animal Species.
• 3. Acute Experiments.
• 4. Chronic Implantation of Electrodes.
• 5. Recording Procedures.
• 6. Methods of Analyzing and Quantifying the EEG.
• 7. Sensory Evoked Response Analysis.
• 8. Focal Electrical Stimulation.
• 9. Electrogenesis of the EEG and Evoked Potentials.
• 10. Assessment of Alertness, Sedation, and the Stages of Sleep.
• 11. Study of Sleep Patterns.
• 12. Abnormal EEG Records.
• 13. Transmitters and EEG Changes.
• 14. Uses and Limitations of Macroelectrode Recordings.
• 15. References.
• 4 Neuropharmacological Responses from Nerve Cells in Tissue Culture.
• 2. Muscle.
• 3. Continuous Cell Lines.
• 4. Glia.
• 5. Explants.
• 6. Dissociated Primary Cell Cultures.
• 7. Discussion.
• 8. References.
• 5 Biochemical Identification of Membrane Receptors: Principles and Techniques.
• 2. Properties of Receptor Interactions and Technical Considerations.
• 3. Examples of Studies on Hormone-Membrane Receptor Interactions.
• 6 Structure-Activity Relations for Neurotransmitter Receptor Agonists and Antagonists.
• 2. Norepinephrine.
• 3. Dopamine.
• 4. 5-Hydroxytryptamine.
• 5. Acetylcholine.
• 6. Histamine.
• 7 Denervation Supersensitivity.
• 2. Quantitative Methods in the Study of Supersensitivity.
• 3. Surgical and Pharmacological Denervation.
• 4. Supersensitivity After Denervation of Sympathetically Innervated Organs.
• 5. Supersensitivity After Denervation of Cholinergically Innervated Organs.
• 6. Supersensitivity in the Central Nervous System.
• 7. Clinical Implications of Supersensitivity and Subsensitivity.