Cell-Mediated Effects of Immunoglobulins

Inhaltsverzeichnis

• 1. Structure and Function of Immunoglobulins.
• Structural Bases of Antibody Functions.
• Immunoglobulin Isotypes.
• Biological Functions of Antibodies.
• Conclusion.
• 2. Structure and Expression of Fc Receptors (FcR).
• Nomenclature.
• Members of the Immunoglobulin Superfamily.
• Members of the Animal Lectin Superfamily.
• Fc Receptors on Microorganisms.
• 3. Cell Activation Via Fc Receptors.
• General View of Cell Activation Through Immunoreceptors.
• A Model of FcR with Specific Function: The Fc Receptor for IgE (Fc? RI).
• A Model of Multifunctional FcR: The Low Affinity Fc Receptors for IgG (Fc? RII and Fc? RIII).
• Specific Functions of Several Fc Receptors.
• A Nontypical Fc Receptor: The Low-Affinity Receptor of IgE: (CD23).
• 4. Fc? R as Negative Coreceptors.
• The Immunoreceptor Family.
• Fc? RIIB Inhibits BCR-Mediated B Cell Activation.
• Fc? RIIB Inhibits FcR-Mediated Mast Cell Activation.
• Fc? RIIB Inhibits TCR-Mediated T Cell Activation.
• Fc? RIIB Inhibits Cell Activation by all ITAM-Based Immunoreceptors.
• The ITIM Motif.
• Biochemical Mechanisms of Negative Regulation by Fc? RIIB.
• Biological Significance of Negative Regulation by Fc? RIIB.
• 5. Internalization through Receptors for Immunoglobulins.
• Endocytosis.
• Phagocytosis.
• Transcytosis.
• 6. Soluble Fc Receptors.
• Soluble Fc? Receptors (sFc? R).
• Soluble Fc? R.
• Other Soluble FcR.
• 7. Fc Receptors and Pathology.
• Genetic Aspects of FcR Expression: Relationship to Diseases.
• Membrane-Bound Fc? R Involvement in Autoimmunity and Inflammation.
• Soluble Fc? R and Fc? R in Pathology: A Marker with a Diagnosis and/or Prognosis Value?.
• Membrane-Bound and Soluble FcR Tools for Immunotherapy?.