Kopplung von Peptiden an Oligoribonukleotide ohne Schutzgruppen von Maximilian Räuchle | ISBN 9783843948661

Kopplung von Peptiden an Oligoribonukleotide ohne Schutzgruppen

von Maximilian Räuchle
Buchcover Kopplung von Peptiden an Oligoribonukleotide ohne Schutzgruppen | Maximilian Räuchle | EAN 9783843948661 | ISBN 3-8439-4866-6 | ISBN 978-3-8439-4866-1

Kopplung von Peptiden an Oligoribonukleotide ohne Schutzgruppen

von Maximilian Räuchle
Peptido RNAs are 5'-phosphorylated oligoribonucleotides connected to the a-amino group of a peptide via a phosphoramidate linkage. Previously, peptido RNAs with statistical chain length distributions could be detected as products of spontaneous reactions between amino acids and ribonucleotides in an aqueous condensation buffer. Although occupying a niche role in today’s biochemistry, the formation of peptido RNAs as possible intermediate evolutionary species may be important in relation to the molecular origin of life. To enable in- depth biophysical studies of these modified RNAs, synthetic protocols for obtaining monodisperse, pure compounds are described in this dissertation.