Cooperativity and Regulation in Biochemical Processes

Inhaltsverzeichnis

• 1 Introducing the Fundamental Concepts.
• 2 The Binding Isotherm.
• 3 Adsorption on a Single-Site Polymer with Conformational Changes Induced by the Binding Process.
• 4 Two-Site Systems: Direct and Indirect Cooperativity.
• 5 Three-Site Systems: Nonadditivity and Long-Range Correlations.
• 6 Four-Site Systems: Hemoglobin.
• 7 Large Linear Systems of Binding Sites.
• 8 Regulatory Enzymes.
• 9 Solvent Effects on Cooperativity.
• Appendices.
• A. Pair and Triplet Correlations between Events.
• B. Localization of the Adsorbent Molecules and Its Effect on the Binding Isotherm.
• C. Transition from Microstates to Macrostates.
• D. First-Order Correction to Nonideality of the Ligand’s Reservoir.
• E. Relative Slopes of Equilibrated and “Frozen-in” BIs in a Multimacrostate System.
• F. Spurious Cooperativity in Single-Site Systems.
• G. The Relation between the Binding Isotherm and the Titration Curve for Two-Site Systems.
• H. Fitting Synthetic Data.
• I. A Comment on the Nomenclature.
• J. Average Binding Constants and Correlation Functions.
• K. Utility Function in a Binding System.
• Abbreviations Used in the Text.
• References.