Applications of Antisense Therapies to Restenosis

Inhaltsverzeichnis

• 1 Restenosis: The Clinical Problem.
• 2 The Pathobiology of Restenosis. A Paradigm from Clinical and Experimental Studies.
• 3 Coronary Repair and Restenosis Cellular Basis for Antisense Approaches.
• 4 Vascular Smooth Muscle Cell Biology and Restenosis.
• 5 Vascular Antisense Therapy Directed Against c-myc, c-myb, and PCNA.
• 6 Phosphorothioate Oligodeoxynucleotides as Inhibitors of gene Expression: Antisenseand Non-Antisense Effects.
• 7 Molecular Therapies for Vascular Disease: Altering the Balance Between Cell growth and Cell Death.
• 8 Oligonucleotides Containing the G-Quartet Sequence Motif.
• 9 Non-G-Quartet, Non-Sequence Specific Antirestenotic Effects of Phosphorothioate Oligodeoxynucleotides.
• 10 Local Delivery of Antirestenotic Drugs.
• 11 Critical Considerations and Future Directions.