1 The Mitochondrial and Bacterial Respiratory Chains: From MacMunn and Keilin to Current Concepts.- 2 The Mitochondrial Enzymes of Oxidative Phosphorylation.- 3 Proton Pumps of Respiratory Chain Enzymes.- 4 Uncoupling of Respiration and Phosphorylation.- 5 Crystallization, Structure, and Possible Mechanism of Action of Cytochrome c Oxidase from the Soil Bacterium Paracoccus denitrificans.- 6 The Structure of Crystalline Bovine Heart Cytochrome c Oxidase.- 7 Electron and Proton Transfer in Heme-Copper Oxidases.- 8 Mechanism of Proton-Motive Activity of Heme-Copper Oxidases.- 9 Oxygen Reduction and Proton Translocation by the Heme-Copper Oxidases.- 10 Transient Spectroscopy of the Reaction between Cytochrome c Oxidase and Nitric Oxide: A New Hypothesis on the Mechanism of Inhibition and Oxygen Competition.- 11 Energy Transduction in Mitochondrial Respiration by the Proton-Motive Q-Cycle Mechanism of the Cytochrome bc1 Complex.- 12 The Crystal Structure of Mitochondrial Cytochrome bc1 Complex.- 13 Structural Aspects of the Cytochrome bc1 Complex.- 14 Structure, Function, and Biogenesis of Respiratory Complex I.- 15 Structure of F1-ATPase and the Mechanism of ATP Synthesis-Hydrolysis.- 16 Mechanism of ATP Synthesis by Mitochondrial ATP Synthase.- 17 Mutational Analysis of ATP Synthase: An Approach to Catalysis and Energy Coupling.- 18 Analysis of the Nucleotide Binding Sites of ATP Synthase and Consequences for the Catalytic Mechanism.- 19 Coupling Structures and Mechanisms in the Stalk of the Bovine Mitochondrial F0F1-ATP Synthase.- 20 The Mitochondrial Carrier Protein Family.- 21 Structure and Evolution of the Metazoan Mitochondrial Genome.- 22 Nuclear Transcription Factors in Cytochrome c and Cytochrome Oxidase Expression.- 23 Suppressor Genetics of the Mitochondrial Energy Transducing System: The Cytochrome bc1 Complex.- 24 Tissue-Specific Expression of Cytochrome c Oxidase Isoforms and Role in Nonshivering Thermogenesis.- 25 Mitochondrial DNA Mutations and Nuclear Mitochondrial Interactions in Human Disease.- 26 Strategy toward Gene Therapy of Mitochondrial DNA Disorders.- 27 The F0F1-ATP Synthase in Cell Proliferation and Aging.- 28 Age-Linked Changes in the Genotype and Phenotype of Mitochondria.- 29 Nucleus-Driven Lesions of mtDNA and Disorders of Nucleus-Encoded Energy Genes.- 30 Aging and Degenerative Diseases: A Mitochondrial Paradigm.- 31 Perspectives on the Permeability Transition Pore, a Mitochondrial Channel Involved in Cell Death.- Author Index.
