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Multidrug resistance is a very serious problem for modern medicine. This book provides a comprehensive overview of the current status of research in the field. Topics include multidrug efflux in gram negative and gram positive bacteria, yeast, and parasitic protozoa and authors emphasise the importance of recent devlopments in molecular biology and genomics. Written by leading international experts the book is required reading for all scientists and medics interested in the problem of multiple drug resistance.
TOC: Microbial Multidrug Efflux: Introduction * Comparative Genomics of Microbial Drug Efflux Systems * The Ostensible Paradox of Multidrug Recognition * Precious Things Come in Little Packages * Staphylococcal Multidrug Efflux Protein QacA * MdfA, an Interesting Model Protein for Studying Multidrug Transport * Enterococcus faecalis Multi-Drug Resistance Transporters: Application for Antibiotic Discovery * Molecular Basis of Multidrug Transport by ATP-Binding Cassette Transporters: A Proposed Two-Cylinder Engine Model * Prokaryote Multidrug Efflux Proteins of the Major Facilitator Superfamily: Amplified Expression, Purification and Characterization * Multidrug Resistance and ABC Transporters in Parasitic Protozoa * The Pleitropic Drug ABC Transporters from Saccharomyces cerevisiae * AcrAB and Related Multidrug Efflux Pumps of Escherischia coli * Genetic Organization and Regulation of Antimicrobial Efflux Systems Processed by Neisseria gonorrhoeae and Neisseria meningitides * Inhibition of Efflux Pumps as a Novel Approach to Combat Drug Resistance in Bacteria * Functions of Tetracycline Efflux Proteins That Do Not Involve Tetracycline * In Search of Natural Substrates and Inhibitors of MDR
TOC: Microbial Multidrug Efflux: Introduction * Comparative Genomics of Microbial Drug Efflux Systems * The Ostensible Paradox of Multidrug Recognition * Precious Things Come in Little Packages * Staphylococcal Multidrug Efflux Protein QacA * MdfA, an Interesting Model Protein for Studying Multidrug Transport * Enterococcus faecalis Multi-Drug Resistance Transporters: Application for Antibiotic Discovery * Molecular Basis of Multidrug Transport by ATP-Binding Cassette Transporters: A Proposed Two-Cylinder Engine Model * Prokaryote Multidrug Efflux Proteins of the Major Facilitator Superfamily: Amplified Expression, Purification and Characterization * Multidrug Resistance and ABC Transporters in Parasitic Protozoa * The Pleitropic Drug ABC Transporters from Saccharomyces cerevisiae * AcrAB and Related Multidrug Efflux Pumps of Escherischia coli * Genetic Organization and Regulation of Antimicrobial Efflux Systems Processed by Neisseria gonorrhoeae and Neisseria meningitides * Inhibition of Efflux Pumps as a Novel Approach to Combat Drug Resistance in Bacteria * Functions of Tetracycline Efflux Proteins That Do Not Involve Tetracycline * In Search of Natural Substrates and Inhibitors of MDR