Biochemistry of Vitamin B6

Inhaltsverzeichnis

• Prologue in Honour of Alexander E. Braunstein 1902–1986.
• The Discovery of Enzymatic Transamination and Its Biological Significance.
• Professor Alexander E. Braunstein; Some Reminiscences.
• Closing Remarks.
• Molecular Biology and Site-Directed Mutagenesis.
• Genes, Biosynthesis, and Intracellular Processing of the Isoenzymes of Aspartate Aminotransferase.
• Structure-Function Relation of the Presequence of a Precursor to Pig Mitochondrial Aspartate Aminotransferase.
• Molecular Cloning and in vivo Expression of the Precursor to Rat Mitochondrial Aspartate Aminotransferase.
• Rat Cytosolic Aspartate Aminotransferase; Molecular Cloning of cDNA and Expression in E. coli.
• D-Amino Acid Aminotransferase from a Thermophile, Bacillus sp. YM-1: Enzymological Properties, Cloning of the Gene, and the Amino Acid Sequence.
• The Subunit Structure of Porcine Ornithine Aminotransferase and Mechanism of Proteolytic Modification of Its Putative Precursors in Mitochondria.
• Hepatic Systems Degrade Tyrosine Aminotransferase.
• Demonstration of Immunochemical Cross-Reactivity of Dopa Decarboxylase and Histidine Decarboxylase Using Antibodies against the Two Enzymes.
• Mechanistic Analysis of the Aspartate Aminotransferase Active Site Mutants — Y70F, K258A, and R292D.
• Mutation of Lysine 258 to Arginine in the Active Site of Aspartate Aminotransferase.
• Bacterial Tryptophan Synthetase: A Multienzyme Complex Which Contains Pyridoxal Phosphate.
• Site-specific Mutations in E. coli Maltodextrin Phosphorylase with Differential Effects on Substrate Binding and Catalysis.
• Aminotransferases.
• Spatial Aspects of Catalysis by Mitochondrial Aspartate Aminotransferase.
• Recent Studies on Mitochondrial Aspartate Aminotransferase: Structure and Mechanism.
• X-Ray Crystallographic, 19F-NMR and UV-Visible Spectroscopic Studies of Pig Heart Cytosolic Aspartate Aminotransferase.
• Studies of the Inactivated Coenzyme in the Beta Sub form of Cytosolic Aspartate Aminotransferase.
• Studies on the Mechanism of Action of Aspartate Aminotransferase by Cryoenzymological and Isotope Techniques.
• Aspartate Aminotransferase from the Thermoacidophile Archaebacterium Sulfolobus solfataricus.
• Coenzyme Reorientations in the Active Sites of Aspartate Aminotransferase Isoenzymes.
• Phosphorus-31 Nuclear Magnetic Resonance Studies on Apoaspartate Aminotransferase Reconstituted with Cofactor Analogues.
• Fourier Transform Infrared Spectroscopic Analysis of Phosphate Bound to the Aspartate Aminotransferase Isoenzymes.
• Carboxylate Inhibition of Apoaspartate Aminotransferase.
• The Reversible Oxidation of Vicinal SH Groups in 4-Aminobutyrate Aminotransferase. Probes of Conformational Changes.
• Branched-Chain Amino Acid Aminotransferase from Escherichia coli.
• Crystallographic and Solution Studies on Phosphoserine Aminotransferase (PSAT) from E. coli.
• Studies on Liver GABA-Transaminase.
• A Novel Aminotransferase Concerned with the Metabolism of Dimethylarginines in Rats.
• Other Vitamin B6-Enzymes of Amino Acid Metabolism.
• Chemical Probes of Substrate Channeling in the E. coli Tryptophan Synthase ?2?2 Bienzyme Complex.
• Phosphorus-31 NMR Study of Pyridoxal 5?-Phosphate Binding to Escherichia coli Tryptophan Synthase Modified by Limited Proteolysis.
• Glutamate Decarboxylase: Preliminary Crystallographic Data.
• Analysis of the Glutamate Decarboxylase Reaction by Membrane Inlet Mass Spectrometry.
• Proteolytic Cleavage of Pig Kidney Dopa Decarboxylase.
• The Reaction of Dopa Decarboxylase with 5?-Hydroxytryptophan Isomers.
• Sequence Studies on Vitamin B6-Dependent Enzymes: Serine Hydroxymethyltransferase and Glutamate Decarboxylase.
• Stereochemistry of the Threonine Cleavage Complex.
• The Substrate Specificity of Tyrosine Phenol-Lyase During the Different Stages of Enzymatic Process.
• Structural and Catalytic Properties of Citrobacter intermedius Tyrosine Phenol-Lyase.
• L-Methionine Y—Lyase: Its Essential Cysteine Residues.
• Diaminopropionate Ammonia-Lyase of Salmonella typhimurium.
• Interactions of Tryptophanase with Substrate Analogues.
• S-Carboxymethylcysteine Synthase from E. coli.
• Copper-Containing Amine Oxidases (EC 1.4.3.6) Have Covalently-Bound PQQ and not PLP as Organic Cofactor.
• Phosphorylases.
• The Role of the Pyridoxal Phosphate in Glycogen Phosphorylase b.
• Phosphorylase Isozymes of Higher Plants.
• The Polarized Single Crystal Electronic Absorption Spectrum of Phosphorylase b.
• Crystallization and Structure Determination of Potato Phosphorylase at 3 Å Resolution.
• Quaternary Structure and Regulatory Properties of Phosphorylase Kinase from Avian Skeletal Muscle.
• Purification and Properties of Smooth Muscle Phosphorylase from Bovine Stomach.
• Thermodynamic Study of the Binding of AMP to Glycogen Phosphorylase a and b.
• Enzyme-Activated and Related Irreversible Inhibitors.
• Enzyme-Activated Inhibitors of Bacterial D-Amino Acid Transaminase as Antimicrobial Agents.
• Selective Inhibition of PLP-Dependent Enzymes by Hydroxylamine Derivatives.
• On the Mechanism of Ornithine Decarboxylase Inhibition by 3-Aminooxypropylamine.
• Kinetic Studies on Binding of Mitochondrial and Cytosolic Aspartate Aminotransferases with Suicide Substrate, Gostatin.
• Inactivation of Bacterial ?-Amino Acid: Pyruvate Transaminase with Se-Hypotaurine.
• Absence of Stereospecificity in the Suicide Inhibition of Ornithine Decarboxylase.
• Enzyme-Activated Irreversible Inhibition of Bacterial and Plant Arginine Decarboxylase, by either Substrate or Product Analogues.
• Cystathionine ?-Synthase and ?-Cystathionase have Conmon Peptide Sequences of the Active Sites and Are Inhibited Similarly by Aminoethoxyvinylglycine.
• Non-Enzymic Reactions of Vitamin B6.
• Micellar Catalysis of Pyridoxal-Dependent Reactions.
• A New Approach to the Study of Pyridoxal 5?-Phosphate Schiff Bases.
• Enthalpy, Entropy and Gibbs Energy Changes Associated with the Ionization of Vitamin B6 Molecules in Water-Dioxane Systems.
• NMR Detection of a Delocalized Carbanion Intermediate in the Transamination Reactions of the Metal Chelates of Schiff Bases of Vitamin B6.
• Copper(II) Chelates of an Intermediate Species Absorbing in the 500-nm Region.
• Co-Ordination Compounds of Pyridoxol with Chromium and Manganese.
• A Novel Method to Study the Topography of Transmembrane Proteins Using Pyridoxal 5?-Phosphate.
• Metabolic, Nutritional, and Medical Aspects.
• Glutamine and Asparagine Transaminases.
• Rat Aspartate Aminotransferase: Regulation of Its mRNA and Its Contribution to Gluconeogenesis.
• Vitamin B6 Deficiency Enhances End-Organ Sensitivity to Steroid Hormones.
• Partial Purification and Characterization of Vitamin B6-P Phosphatases from Human Erythrocytes.
• Pyridoxine Uptake by Proximal Tubular Epithelial Cells Isolated from Rat Kidney.
• Influence of Vitamin B6 Nutritional Status upon Plasma Kinetics of PLP after I. V. Dosing to Rats.
• Vitamin B6- Status of Finnish and Dutch Elderly.
• Metabolism of Vitamin B6 by Human Subjects with and without Normal Liver Function.
• Vitamin B6 Supplementation in Juvenile Neuronal Ceroid Lipofuscinosis Patients.
• Bacterial Methionine -Lyase as a Possible Antitumor Agent.
• A New Approach to the Pathogenetic Treatment of Psoriasis Using Coenzyme Inhibitors.
• Biotechnology.
• Enantiomer Synthesis of Amino Acids with Pyridoxal Enzymes.
• Vitamin B6-Dependent Reactions in Organic Solvents.
• ?—Amino—?— Caprolactam Racemase for L-Lysine Production.
• Enzymatic Production of L-Cysteine from DL-2-Aminothiazoline- 4-Carboxylic Acid.
• Industrial Production of L-Tryptophan from Indole and DL-Serine with two PLP-Dependent Enzymes.