Human Genetic Variation in Response to Medical and Environmental Agents: Pharmacogenetics and Ecogenetics

Inhaltsverzeichnis

• Pharmacogenetics and Ecogenetics: The Problem and Its Scope.
• I. Multifactorial Pharmacogenetics in Man.
• Multifactorial Inheritance and Heritability in Pharmacogenetics.
• Human Pharmacokinetics.
• Twin Studies in Pharmacogenetics.
• Search for Single Gene Effects in Multifactorial Inheritance in Pharmacogenetics.
• II. Monogenic Pharmacogenetics in Man.
• G6PD Variants.
• Pseudocholinesterase Variation.
• Aromatic Amines and Hydrazines, Drug Acetylation, and Lupus Erythematodes.
• Polymorphism of Human Serum Paraoxonase.
• Malignant Hyperthermia.
• Drug Sensitivity in Hereditary Hepatic Porphyria.
• Assets and Limitations of Animal Models.
• III. Human Psychopharmacogenetics.
• Psychopharmacogenetics: An Overview and New Approaches.
• Alcohol and Alcoholism.
• Human Biochemical Genetics of Plasma Dopamine-?-Hydroxylase and Erythrocyte Catechol-O-Methyltransferase.
• I. Human Genetics and Nutritional Problems.
• Intestinal Lactase Polymorphisms and Dairy Foods.
• Genetic and Nongenetic Hyperlipidemia and Western Diets.
• Can Iron Fortification of Flour Cause Damage to Genetic Susceptibles (Idiopathic Haemochromatosis and ?-Thalassaemia Major)?.
• II. Genetic Variation in Mutagenesis and Carcinogenesis.
• Genetic Aspects of Induced Mutation.
• The Ah Locus: Aromatic Hydrocarbon Responsiveness... of Mice and Men.
• Aryl Hydrocarbon Hydroxylase in Man and Lung Cancer.
• An Overview of Animal and Microbial Test Systems for Carcinogenesis and Mutagenesis: Problems With Human Variation.
• III. General Problems in Ecogenetics.
• Ecogenetics: A View From the U. S. President’s Science Advisory Office.
• Bioethical Problems in Pharmacogenetics and Ecogenetics.