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Recent years have witnessed an explosion of knowledge lea-
ding to a molecular understanding of the mechanisms of ac-
tion of calcium on excitation and contraction coupling and
its role in the regulation of contractility. This book
highlights the most recent progress as well as providing a
historial perspective of the field. It presents a concise
and comprehensive overview of our current knowledge regar-
ding calcium channels and regulatory proteins as well as in-
tracellular calcium handling and the mechanisms underlying
the activation of contractile proteins. It also describes
how these basic mechanisms have been adapted in various
types of muscle, especially in cardiac and smooth muscle.
ding to a molecular understanding of the mechanisms of ac-
tion of calcium on excitation and contraction coupling and
its role in the regulation of contractility. This book
highlights the most recent progress as well as providing a
historial perspective of the field. It presents a concise
and comprehensive overview of our current knowledge regar-
ding calcium channels and regulatory proteins as well as in-
tracellular calcium handling and the mechanisms underlying
the activation of contractile proteins. It also describes
how these basic mechanisms have been adapted in various
types of muscle, especially in cardiac and smooth muscle.
