Session I — Pharmacology.- Tolerance from the Pharmacokinetic and Pharmacodynamic Viewpoints.- Does Tolerance Develop During Long-Acting Nitrate Therapy? A Critical Review.- Pharmacokinetics of Isosorbide Dinitrate During Tolerance Development.- Discussion.- Session II — Hemodynamics.- Lack of Tolerance Development to the Hemodynamic Effects of Nitrates in Patients with Chronic Congestive Heart Failure.- Discussion.- Hemodynamic Effects of 5-Isosorbide Mononitrate During Acute and Chronic Administration.- Discussion.- Investigations to Demonstrate Nitrate Tolerance in Peripheral Vessels by Means of a Simple Hemodynamic Test.- Discussion.- Hemodynamic and Ventricular Dynamic Investigations of Nitrate Tolerance.- Discussion.- Treatment of Congestive Heart Failure with Vasodilators: Comparison of Acut and Long-Term Effects of Various Agents.- Discussion.- Long-Term Isosorbide Dinitrate Therapy for Pulmonary Hypertension in Patients with Chronic Obstructive Lung Disease.- Discussion.- Development of Tolerance and Peripheral Hemodynamic Effects of Molsidomine.- Discussion.- Session III — Coronary Heart Disease.- Acute and Chronic Effects of Oral Isosorbide Dinitrate in Patients with Angina.- Discussion.- Tolerance in Patients with Coronary Heart Disease Under Chronic Treatment with Isosorbide Dinitrate?.- Discussion.- Long-Term Effects of High-Dose ISDN Therapy in Patients with Coronary Heart Disease.- Discussion.- Evaluation of Cross-Tolerance Between Long-Term Oral Isosorbide Dinitrate and Sublingual Nitroglycerin: Assesssment by Exercise Testing.- Discussion.- The Effects of Long-Acting Nitrates on Ambulatory ECG Changes in Patients with Angina Pectoris Treated for 1 Week.- Discussion.- Chronic Treatment of Ischemic Heart Disease with Isosorbide Dinitrate Retard Tablets: Evidence of Preserved Hemodynamic Response to a Sublingual Dose of 5 mg.- Discussion.
