Designing crystallization based-enantiomeric separation for chiral compound-forming systems in consideration of polymorphism and solvate formation

Even though almost all chemical and physical properties of two enantiomers of a chiral compound are identical, each of them can show different activities in chiral environments. Therefore, purification of single enantiomers plays a vital role, in particular for pharmaceuticals. Enantioseparation is an indispensable task which gained great attention in the last decades. Among separation methods, crystallization is considered as an outstanding approach due to its low cost (compared to e. g. chromatography, membrane processes). However, there are just a few single enantiomers available on the market produced via crystallization up to now. This thesis contributes a systematic study of enantioseparation which focuses on the major chiral group i. e. compound-forming racemates considering effects of polymorphism and solvate formation.