Multiphysics Modeling and Quantification of Early Atherosclerosis

In this thesis, an in silico approach to a better understanding of the onset and early stages of atherosclerosis is taken. To this end, several mathematical multiphysics models are developed, numerically treated and parameterized based on existing experimental results. The models allow to identify potential atherosclerosis-prone regions within patient-specific cardiovascular systems and to investigate the stability of early plaques based on measurable in vivo inputs. In addition, future experimental investigations for biologists to take up are suggested.