Bringing Paracoccus to biotechnology – from versatile phenotypes to a SynBio Chassis

A novel microbial chassis from Paracoccus spp. was developed to support circular bioeconomy goals. A genetic toolbox enabling PET monomer utilization was constructed. Whole-genome sequencing led to reclassification of uncharacterized strains. Metabolic flux analysis and a curated genome-scale model (iPpan24) revealed ED pathway preference and predicted product yields, enabling model-guided strain engineering.