Nephrotoxicity in the experimental and clinical situation

Inhaltsverzeichnis

• 1. Fixation of renal tissue for cytochemical evaluation.
• 2. The application of histochemistry at the light microscopic level to the study of nephrotoxicity.
• 3. Cryomicrotomy of renal tissue, and the use of X-ray microanalysis and autoradiography at the light and electron microscopic levels.
• 4. Fixation of kidney tissue for morphometric study.
• 5. Correlating structural and functional changes in nephrotoxic renal injury.
• 6. Naturally occurring renal disease in non-human primates.
• 7. Chemically induced epithelial tumours and carcinogenesis of the renal parenchyma.
• 8. Assessment of the kidney in relation to blood pressure regulation.
• 9. Renal slices and perfusion.
• 10. The use of single nephron techniques in renal toxicity studies.
• 11. Prostaglandins and other eicosanoids.
• 12. Xenobiotic metabolism in the mammalian kidney.
• 13. Metabolism of glutathione in the kidney.
• 14. Metabolic activation of halogenated chemicals and its relevance to nephrotoxicity.