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![]( "Buchcover ISBN 9780470119044")
First Edition Reviews:
„The book successfully brings together the field of behavioralneuroscience and the rewards and insights that can be gained usingthis approach. I would recommend that every behavioral scientisthas at least two copies, one for their own use and one that will beon permanent load to their students, post-doctoral students andcolleagues in molecular biology.“ (Trends in PharmaceuticalSciences)
„the overall impression is of a helpful guide taking the readerstep by step through the complexities of animal behavioralresearch.“ (Nature Neuroscience)
„succeeds as a useful introduction to the realm of behavioralphenotyping for those interested in creating or using the large andincreasing number of promising targeted mutant mice.“ (Trends inNeurosciences)
What's Wrong With My Mouse?
Behavioral Phenotyping of Transgenic and Knockout Mice
von Jacqueline N. CrawleyDr. Jacqueline N. Crawley, author of the First and Second Editionsof What's Wrong with My Mouse? Behavioral Phenotyping ofTransgenic and Knockout Mice, continues to field calls ande-mails from molecular geneticists who ask: how do I runbehavioral assays to find out what's wrong with my mouse?
Turn to What's Wrong with My Mouse? to discover thewealth of mouse behavioral tasks and to get the guidance you needto select the best methods and necessary controls. Chapters areorganized by behavioral domain, including measurements of generalhealth, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and rewardbehaviors in mutant mice. Throughout the chapters, new behavioraltasks and new research discoveries have been added, bringing theSecond Edition up to date with the latest science. In addition, theSecond Edition includes two new chapters:
„Neurodevelopment and Neurodegeneration“ discusses mousebehavioral tasks relevant to neurodevelopmental diseases, such asmental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophiclateral sclerosis.
„Putting It All Together“ recommends strategies for optimizing abattery of behavioral phenotyping tests to address your specifichypotheses about gene functions.
The final chapter, „The Next Generation,“ examines new andemerging technologies.
Throughout the book, the use of behavioral testing equipment isillustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic andknockout mouse models are provided, as well as references to theprimary literature and step-by-step methods protocols. Thesefeatures, along with a comprehensive index, listings of databaseand vendor websites, and an extensive list of references, make thisbook a valuable and practical resource for students andresearchers.
Turn to What's Wrong with My Mouse? to discover thewealth of mouse behavioral tasks and to get the guidance you needto select the best methods and necessary controls. Chapters areorganized by behavioral domain, including measurements of generalhealth, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and rewardbehaviors in mutant mice. Throughout the chapters, new behavioraltasks and new research discoveries have been added, bringing theSecond Edition up to date with the latest science. In addition, theSecond Edition includes two new chapters:
„Neurodevelopment and Neurodegeneration“ discusses mousebehavioral tasks relevant to neurodevelopmental diseases, such asmental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophiclateral sclerosis.
„Putting It All Together“ recommends strategies for optimizing abattery of behavioral phenotyping tests to address your specifichypotheses about gene functions.
The final chapter, „The Next Generation,“ examines new andemerging technologies.
Throughout the book, the use of behavioral testing equipment isillustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic andknockout mouse models are provided, as well as references to theprimary literature and step-by-step methods protocols. Thesefeatures, along with a comprehensive index, listings of databaseand vendor websites, and an extensive list of references, make thisbook a valuable and practical resource for students andresearchers.
