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Buchcover - Six-Membered Transition States in Organic Synthesis - ISBN 978-0-470-19904-6
Fifty years ago, Zimmerman and Traxler put forth an audacioussuggestion that in a reaction they were studying six of the atomswere oriented in a ring as the two components approached eachother. This was at a time when no one considered the detailedorientation of molecules during reactions. This Zimmerman-Traxlerhypothesis is now known to be not only correct for their reaction, but in fact true in many other chemical processes. As such, theidea is one of the fundamental organizing principles of organicchemistry. Yang (Montana State Univ.) has provided a usefulcollection of all reactions currently understood to proceed in suchfashion. These reactions are contained in 4 chapters: „[3,3] -Sigmatrophic Rearrangements,“ „Aldol Reactions,“ „Metal AllylationReactions,“ and „Stereoselective Reductions.“ This small bookshould be useful for both synthetic chemists and those studyingmechanisms, particularly stereochemistry, of organic reactions. Summing Up: Recommended. Upper-division undergraduatethrough professional collections. -- A. Fry, WesleyanUniversity (CHOICE, March 2009)
It is an interesting, well-written, and carefully researchedbook, full of useful details for practioners and students oforganic chemistry. (Journal of the American ChemicalAssociation, July 2, 2008)
Six-Membered Transition States in Organic Synthesis
von Jaemoon YangHow stereoselective reactions occur through six-membered transition states
This book is a definitive guide for furthering readers' understanding of the amazing features of six-membered transition states in stereoselective organic reactions. Comprehensive and logically organized, it:
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Covers reactions classified in four categories: [3,3]-sigmatropic rearrangements, aldol reactions, metal allylation reactions, and stereoselective reductions
*
Includes „General Considerations“ for each category in which the author presents computational studies that support a proposal of a six-membered state
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Provides a thorough discussion of each reaction category, including an introduction and history, a discussion of the corresponding six-membered transition state, and details of synthetic applications in natural product synthesis
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Incorporates real-life applications of these transition states to the total syntheses of biologically active natural products
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Covers literature up to 2006, with the original references cited for further study
This is a premier reference for organic chemists, medicinal chemists, and physical organic chemists and researchers in industries and institutes focusing on fine chemicals, including pharmaceuticals, agriculture/biotech, and polymers/materials. It is also an illuminating text for upper-level undergraduate and graduate students in organic chemistry. The author's primary goal is to assist professors, researchers, and students in proposing reasonable transition states for the description of newly discovered stereo-selective reactions.
This book is a definitive guide for furthering readers' understanding of the amazing features of six-membered transition states in stereoselective organic reactions. Comprehensive and logically organized, it:
*
Covers reactions classified in four categories: [3,3]-sigmatropic rearrangements, aldol reactions, metal allylation reactions, and stereoselective reductions
*
Includes „General Considerations“ for each category in which the author presents computational studies that support a proposal of a six-membered state
*
Provides a thorough discussion of each reaction category, including an introduction and history, a discussion of the corresponding six-membered transition state, and details of synthetic applications in natural product synthesis
*
Incorporates real-life applications of these transition states to the total syntheses of biologically active natural products
*
Covers literature up to 2006, with the original references cited for further study
This is a premier reference for organic chemists, medicinal chemists, and physical organic chemists and researchers in industries and institutes focusing on fine chemicals, including pharmaceuticals, agriculture/biotech, and polymers/materials. It is also an illuminating text for upper-level undergraduate and graduate students in organic chemistry. The author's primary goal is to assist professors, researchers, and students in proposing reasonable transition states for the description of newly discovered stereo-selective reactions.
