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![]( "Buchcover ISBN 9780470749715")
„This book provides a comprehensive review of the many approachesundertaken over the yearsto develop peptide-based andpeptide-mimetic-based drugs.“ (Journal of MedicinalChemistry, June 2010)
Peptide and Protein Design for Biopharmaceutical Applications
herausgegeben von Knud J. JensenPeptides serve as effective drugs in the clinic today. However theinherent drawbacks of peptide structures can limit their efficacyas drugs. To overcome this researchers are developing new methodsto create 'tailor-made' peptides and proteins withimproved pharmacological properties.
Design of Peptides and Proteins provides an overview ofthe experimental and computational methods for peptide and proteindesign, with an emphasis on specific applications for therapeuticsand biomedical research. Topics covered include:
* Computer modeling of peptides and proteins
* Peptidomimetics
* Design and synthesis of cyclic peptides
* Carbohydrates in peptide and protein design
* De novo design of peptides and proteins
* Medical development applications
* An extended case study - the design of insulinvariants
Design of Peptides and Proteins presents thestate-of-the-art of this exciting approach for therapeutics, withcontributions from international experts. It is an essentialresource for academic and industrial scientists in the fields ofpeptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry andmedicinal/pharmaceutical chemistry.
Design of Peptides and Proteins provides an overview ofthe experimental and computational methods for peptide and proteindesign, with an emphasis on specific applications for therapeuticsand biomedical research. Topics covered include:
* Computer modeling of peptides and proteins
* Peptidomimetics
* Design and synthesis of cyclic peptides
* Carbohydrates in peptide and protein design
* De novo design of peptides and proteins
* Medical development applications
* An extended case study - the design of insulinvariants
Design of Peptides and Proteins presents thestate-of-the-art of this exciting approach for therapeutics, withcontributions from international experts. It is an essentialresource for academic and industrial scientists in the fields ofpeptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry andmedicinal/pharmaceutical chemistry.
