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![]( "Buchcover ISBN 9781118180761")
„This book fills time needs of ADME researchers andprovides a fine reference book for scientists engaged in the areasof medicinal chemistry, pharmaceutics, bioanalytical sciences, pharmacology and toxicology in academia and pharmaceuticalindustry.“ (British Toxicology Society, 1 July2013)
ADME-Enabling Technologies in Drug Design and Development
herausgegeben von Donglu Zhang und Sekhar SurapaneniA comprehensive guide to cutting-edge tools in ADME research
The last decade has seen tremendous progress in the developmentof analytical techniques such as mass spectrometry and molecularbiology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME).
ADME-Enabling Technologies in Drug Design and Developmentfocuses on the current state of the art in the field, presenting acomprehensive review of the latest tools for generating ADME datain drug discovery. It examines the broadest possible range ofavailable technologies, giving readers the information they need tochoose the right tool for a given application, a key requisite forobtaining favorable results in a timely fashion for regulatoryfilings. With over thirty contributed chapters by an internationalteam of experts, the book provides:
* A thorough examination of current tools, covering bothelectronic/mechanical technologies and biologically based ones
* Coverage of applications for each technology, including keyparameters, optimal conditions for intended results, protocols, andcase studies
* Detailed discussion of emerging tools and techniques, from stemcells and genetically modified animal models to imagingtechnologies
* Numerous figures and diagrams throughout the text
Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalyticalscience will find ADME-Enabling Technologies in Drug Design andDevelopment an invaluable guide to the entire drug developmentprocess, from discovery to regulatory issues.
The last decade has seen tremendous progress in the developmentof analytical techniques such as mass spectrometry and molecularbiology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME).
ADME-Enabling Technologies in Drug Design and Developmentfocuses on the current state of the art in the field, presenting acomprehensive review of the latest tools for generating ADME datain drug discovery. It examines the broadest possible range ofavailable technologies, giving readers the information they need tochoose the right tool for a given application, a key requisite forobtaining favorable results in a timely fashion for regulatoryfilings. With over thirty contributed chapters by an internationalteam of experts, the book provides:
* A thorough examination of current tools, covering bothelectronic/mechanical technologies and biologically based ones
* Coverage of applications for each technology, including keyparameters, optimal conditions for intended results, protocols, andcase studies
* Detailed discussion of emerging tools and techniques, from stemcells and genetically modified animal models to imagingtechnologies
* Numerous figures and diagrams throughout the text
Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalyticalscience will find ADME-Enabling Technologies in Drug Design andDevelopment an invaluable guide to the entire drug developmentprocess, from discovery to regulatory issues.
