A Handbook for DNA-Encoded Chemistry

This book comprehensively describes the development and practiceof DNA-encoded library synthesis technology. Together, the chaptersdetail an approach to drug discovery that offers an attractiveaddition to the portfolio of existing hit generation technologiessuch as high-throughput screening, structure-based drug discoveryand fragment-based screening. The book:
* Providesa valuable guide for understanding and applying DNA-encodedcombinatorial chemistry
* Helpschemists generate and screen novel chemical libraries of large sizeand quality
* Bridgesinterdisciplinary areas of DNA-encoded combinatorial chemistry- synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
* Showsmedicinal and pharmaceutical chemists how to efficiently broadenavailable „chemical space“ for drug discovery
* Providesexpert and up-to-date summary of reported literature forDNA-encoded and DNA-directed chemistry technology and methods