Dermatopathology

Inhaltsverzeichnis

• Overview of Dermatopathology.
• 1. Cutaneous Anatomy.
• Embryology.
• Epidermis.
• Stratum Basale (Basal Layer).
• Stratum Spinosum (Prickle Cell Layer).
• Stratum Granolosum (Granular Layer).
• Stratum Corneum (Horny Layer).
• Epidermal Appendages.
• Hair.
• Sebaceous Glands.
• Apocrine Glands.
• Eccrine Glands.
• Other Epidermal Cells.
• Basement Membrane Zone (BMZ).
• Dermis.
• Connective Tissue.
• Cutaneous Nerves.
• Blood Vessels.
• Muscles.
• 2. Basic Pathologic Changes.
• Epidermal Changes.
• Dermal Changes.
• Cytology.
• Lymphocytes.
• Plasma Cells.
• Neutrophils (Polymorphonuclear Leukocytes).
• Eosinophils.
• Phagocytes.
• Giant Cells.
• Mast Cells.
• Fibroblasts.
• 3. Lesion Morphology.
• Primary Lesions.
• Secondary Lesions.
• 4. Practical Aspects.
• Obtaining a Biopsy Specimen.
• Fixation.
• Orientation.
• Staining.
• Adjunctive Techniques.
• Immunofluorescence (IF).
• Immunohistochemistry.
• Electron Microscopy.
• How to Approach a Slide.
• Histopathology of Cutaneous Disease.
• 5. Inflammatory Conditions.
• Infections.
• Viral Diseases.
• Herpes Viruses.
• Pox Viruses.
• Papilloma Viruses.
• Bacterial Diseases.
• Impetigo.
• Actinomycosis.
• Mycobacterial Infections.
• Syphilis.
• Fungal Diseases.
• Scabies.
• Dermatoses.
• Psoriasiform Dermatoses.
• Psoriasis.
• Pustular Psoriasis.
• Pustular Bacterid.
• Parapsoriasis.
• Pityriasis Rosea (PR).
• Lichen Planus (LP).
• Dermatitis.
• Acute Spongiotic Dermatitis.
• Chronic Dermatitis.
• Lichen Simplex Chronicus (LSC).
• Vasculitis.
• Polyarteritis Nodosa.
• Panniculitis.
• Erythema Multiforme (EM).
• Toxic Epidermal Necrolysis.
• Cutaneous Lymphoid Hyperplasia.
• Bullous Diseases.
• Pemphigus.
• Pemphigus Vegetans.
• Pemphigus Foliaceus.
• Bullous Pemphigoid.
• Dermatitis Herpetiformis (DH).
• Porphyria Cutanea Tarda.
• Connective Tissue Diseases.
• Lupus Erythematosus (LE).
• Discoid Lupus Erythematosus (DLE).
• Systemic Lupus Erythematosus (SLE).
• Subacute Lupus Erythematosus.
• Dermatomyositis.
• Morphea.
• Lichen Sclerosus et Atrophicus (LSA).
• Granulomatous and Fibrotic Processes.
• Granuloma Annulare.
• Sarcoidosis.
• Rosacea.
• Foreign Body Granuloma.
• Granuloma Faciale.
• Dermatofibroma and Histiocytoma.
• Dermatofibrosarcoma Protuberans.
• Juvenile Xanthogranuloma.
• Xanthoma.
• 6. Tumors.
• Pigmented Lesions.
• Lentigo.
• Simple Lentigo.
• Actinic Lentigo.
• Lentigo Maligna.
• Melanocytic Nevus.
• Congenital Nevus.
• Halo Nevus.
• Spindle and Epithelioid Nevus (Spitz Nevus).
• Recurrent Nevus.
• Dysplastic Nevus.
• Blue Nevus.
• Malignant Melanoma.
• General Aspects.
• Clinical Subtypes.
• Benign Proliferations and Tumors.
• Epidermal Proliferations.
• Epidermal Nevus.
• Darier’s Disease.
• Hailey-Hailey Disease.
• Acanthosis Nigricans.
• Seborrheic Keratosis.
• Appendageal Proliferations.
• Senile Sebaceous Hyperplasia.
• Cysts.
• Syringoma.
• Pilomatricoma (Malherbe Tumor).
• Cylindroma.
• Eccrine Tumors.
• Hidrocystoma.
• Dermal Proliferations.
• Mast Cell Infiltrates.
• Leiomyoma.
• Neurofibroma.
• Neurilemmoma.
• Skin Tag.
• Malignant and Premalignant Epidermal Tumors.
• Actinic Keratosis.
• Porokeratosis.
• Bowen’s Disease.
• Paget’s Disease.
• Basal Cell Carcinoma.
• Fibroepithelioma of Pinkus.
• Squamous Cell Carcinoma.
• Keratoacanthoma.
• Vascular Proliferations.
• Hemangioma.
• Pyogenic Granuloma.
• Angiokeratoma.
• Lymphangioma.
• Glomus Tumor.
• Kaposi’s Sarcoma.
• Angiosarcoma.
• Malignant Infiltrates.
• Cutaneous Metastases.
• Lymphoma and Leukemia.
• Mycosis Fungoides.
• Histiocytosis X.
• Invisible Dermatoses.
• Further Readings.