Genetic Mosaics and Chimeras in Mammals

Inhaltsverzeichnis

• Use of Chimeras and Cell Aggregations to Study Developmental Potency, Gene Expression, Control of Phenotype, and Tumor Origin.
• Reversion of malignancy and normalized differentiation of teratocarcinoma cells in chimeric mice.
• Viable chimeras produced from normal and parthenogenetic mouse embryos.
• Ovarian teratomas in mice are derived from oocytes that have completed the first meiotic division.
• Growth control in chimeras.
• Attempts at locating the site of action of genes affecting behavior.
• Fine structure of cells in embryos chimeric for mutant genes at the T/t locus.
• An analysis of differentiation in coaggregation cultures between mouse neuronal and tumor cells.
• The use of mosaics and experimental chimeras to study the pathogenesis of neoplasia.
• Antibodies to allozymes as potential cell markers for chimeric mouse studies.
• Use of Chimeras and Mutational or Disjunctional Mosaics to Study Gamete Differentiation, Sexual Development, and Origin of the Germline.
• Reproduction in single-sex chimeras.
• Germ cells in XX ? XY mouse chimeras.
• Use of the sex reversed gene (Sxr) to investigate functional sex reversal and gonadal determination in mammals.
• Why not androgynes among mammals?.
• Cell interactions in the sex organs of sex reversed mice heterozygous for testicular feminization.
• Spontaneous sex mosaicism in BALB/cWt mice.
• Evidence from mutable genes concerning the origin of the germ line.
• X Chromosome Inactivation and Derepression.
• Bimodal distribution of ?-galactosidase activities in mouse embryos.
• Biochemical studies on X-chromosome activity in preimplantation mouse embryos.
• Hypoxanthine guanine phosphoribosyl transferase expression in early mouse development.
• The direct demonstration of an X-chromosome dosage effect prior to inactivation.
• Use ofteratocarcinoma stem cells as a model system for the study of X-chromosome inactivation in vitro.
• The stability of X-chromosome inactivation: studies with mouse-human cell hybrids and mouse teratocarcinomas.
• Studies of human-mouse cell hybrids with respect to X-chromosome inactivation.
• X-Chromosome Nonrandomness: Imprinting, Selection.
• Preferential inactivation of the paternally derived X chromosome in mice.
• Preferential expression of the maternally derived X chromosome in extraembryonic tissues of the mouse.
• In search of nonrandom X inactivation: studies of the placenta from newborns heterozygous for glucose-6-phosphate dehydrogenase.
• The use of mouse X-autosome translocations in the study of X-inactivation pathways and nonrandomness.
• Selection and cell communication as determinants of female phenotype.
• Mathematical and Statistical Analyses of Mosaic Patterns.
• Clonal growth versus cell mingling.
• Combinatorial and computer analysis of random mosaics.
• Data analysis of four X-chromosome inactivation experiments.