Infection, Tumors and Autoimmunity

Inhaltsverzeichnis

Chapter 1 Infections, Tumors and Autoimmunity
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) Carlo Perricone, Yehuda Shoenfeld
Possible role of infections in the pathogenesis of autoimmune liver diseases Daniel S. Smyk and Dimitrios P. Bogdanos
GP2 – The link between innate and acquired immune system in the intestine Dirk Roggenbuck, Dirk Reinhold, Dimitrios P. Bogdanos, Karsten Conrad
Vitamin D in infection and autoimmunity E. Borella, Y. Shoenfeld
Clinical implications of anti-rods and rings autoantibodies in hepatitis C patients treated with interferon/ribavirin therapy S. John Calise, Wendy C. Carcamo, and Edward K. L. Chan
The hyperferritinemic syndrome in infection and autoimmunity Cristina Rosário, Yehuda Shoenfeld
The fate of the Ro autoantigen-associated Y RNAs in Coxsackievirus-infected cells Ger J. M. Pruijn, Dirk den Braanker, Qian Feng, Frank J. van Kuppeveld
Autoantibodies to tumor-associated antigens (TAAs) as biomarkers in the immunodiagnosis of cancer Liping Dai, Pengfei Ren, Xinxin Liu, Carlos A. Casiano, Jian-Ying Zhang
Immunoproteomic profiling of autoantibodies in prostate cancer: a health disparities perspective Tino W. Sanchez, Anamika Basu, Saied Mirshahidi, Chen Chien-Shing, Susanne Montgomery, Colwick Wilson, Jianying Zhang, Nathan Wall and Carlos A. Casiano
Characterisation of novel autoantibody biomarkers in oncology and autoimmunity Will Colón, Colin Wheeler, Ezam Uddin, Nicholas Workman, Pooja Agashe, Tim Vyse and Michael B. McAndrew
Chapter 2 Pathogenesis and Therapy of Autoimmune Diseases – Novel Aspects
The role of neutrophil extracellular traps (NETs) in autoimmunity and generation of autoantibodies Elaine F. Kenny & Arturo Zychlinsky
Revisiting the cell death paradigm in systemic autoimmune diseases Felipe Andrade
NETs and ANCA-associated vasculitides Elena Csernok
Towards understanding the pathogenesis of granulomatosis with polyangiitis: The role of neutrophil extracellular traps C. Lange, E. Csernok, J. U. Holle
Aggregation of NETs: flipping the switch to resolution of inflammation Christine Schorn, Luis Munoz, Deborah Kienhöfer, Martin Herrmann, and Markus Hoffmann
Memory plasma cells in autoimmunity – An update Falk Hiepe
Protective natural autoantibodies in atherogenesis and autoimmunity Gregg J. Silverman and Caroline Grönwall
The interface between primary immunodeficiency and systemic lupus erythematosus Sandro F. Perazzio, Magda Carneiro-Sampaio, Luis E. C. Andrade
Inherited defects in nucleic acid metabolism and autoimmunity Stefanie Kretschmer, Nadja König, Min Ae Lee-Kirsch
Induction of autoimmunity by defects of intracellular nucleases: Mouse models for Aicardi-Goutières syndrome Axel Roers
Anti-AT1R and anti-ETAR autoantibodies from patients with SSc and their agonistic effects A. Kill, Christoph Tabeling, Anja A. Kühl, J. Günther, M. O. Becker, Harald Heidecke, D. Dragun, G. R. Burmester, G. Riemekasten
The use of Aptamers as a new tool for the treatment of autoantibody associated diseases G. Wallukat, A. Haberland, S. Berg, E. J. Freyse, E. Salzsieder, W. Schulze, I. Schimke
Harnessing parasitic infection to treat autoimmunity Miri Blank, Lachnish Jordan, Bashi Tomer and Yehuda Shoenfeld
Chapter 3 Immune Reactions against Drugs
Clinical relevance of anti-drug antibodies Arno Kromminga
Mycophenolic acid and ribavirin induce cytoplasmic Rods and Rings (RR) structures in vivo, but only ribavirin induces anti-RR autoantibodies Gerson D. Keppeke, Sandro F. Perazzio, Monica S. Prado, Edward K. L. Chan, Luis Eduardo C. Andrade
Effects of intracellular glutamine levels on the reversible assembly of cytoplasmic rod and ring autoantigenic structures S. John Calise, Wendy C. Carcamo, Claire Krueger, Daniel L. Purich, and Edward K. L. Chan
Chapter 4 Autoantibodies in Systemic Autoimmune Rheumatic Diseases
4.1 Connective Tissue Diseases
Anti-Mup44 autoantibodies in inclusion-body myositis Helma Pluk, Megan Herbert, Judith Stammen-Vogelzangs, Baziel G. van Engelen, Ger J. M. Pruijn
Autoantibody profiling in idiopathic inflammatory myopathies: Validation of the myositis antigens Mi-2a, MDA5, NXP2 and SAE1 in a line immune assay L. Komorowski, W. Meyer, T. Scheper, W. Schlumberger, A. Ott, P. J. Charles, C. Probst
Evaluation of recombinant TIF1-γ in a line immune assay for the detection of autoantibodies in idiopathic inflammatory myopathies C. Probst, L. Komorowski, W. Meyer, T. Scheper, A. Ott, P. J. Charles, K. Danko, L. Bodoky, H. Chinoy, W. Schlumberger
Autoantibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) a novel biomarker for statin associated necrotizing myopathies Makoto Miyara, Olivier Benveniste, Jean-Luc Charuel, Alexander Shikhman, Olivier Boyer, Joe Philips, Lucile Musset, Michael Mahler
Autoantibody signatures of connective tissue disease patients identified with a bead-based assays approach Angelika Lueking, Petra Budde, Heike Goehler, Jessica Schwermann, Martin Gamer, Klaus Marquardt, Anna Telaar, Daniel Chamrad, Carmen Theek, Matthias Schneider, Peter Schulz-Knappe
Identification of novel autoantibody signatures reflecting the heterogeneity in systemic lupus erythematosus P. Budde, A. Lueking, S. Vordenbäumen, H. Göhler, M. Gamer, K. Marquardt, A. Telaar, D. Chamrad, C. Theek, B. Ostendorf, P. Schulz-Knappe, M. Schneider
What is the clinical significance of anti-Sm-antibodies in SLE patients? A comparison with anti-dsDNA-antibodies and C3 Alexandra Richartz, Thomas Rose, Cornelia Dähnrich, Anke Rosemann, Fidan Barkhudarova, Wolfgang Schlumberger, Gerd-Rüdiger Burmester, Karl Egerer, Robert Biesen and Falk Hiepe
Clinical evaluation of total and high avidity anti-dsDNA antibody EIA for the diagnosis of systemic lupus erythematosus Pengjie Wan, Shuxia Zhou, Hua Cao, Weiping Li, Doug Scott, Joel Hardy, Tony Presitigiacomo, Jie Zheng
Significance of anti-C1q antibody detection in SLE patients with lupus nephritis Ivana Stiborová, Vlastimil Král, Stanislava Blažíčková
4.2 Rheumatoid Arthritis
Autoantibodies in rheumatoid arthritis: predictors of disease, prognosticators of outcome and pathogenic players Markus Hoffmann, Karin Lundberg and Günter Steiner
Antibodies against carbamylated proteins in different stages of rheumatoid arthritis Leendert A. Trouw
Development and initial use of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides in rheumatoid arthritis patients Johan Rönnelid, Linda Mathsson, Mats Nystrand, Lars Klareskog, Monika Hansson
The anti-CCP2 is the anti-citrullinated protein antibody (ACPA) with highest diagnostic value in rheumatoid arthritis E. Grenmyr and Y. Sommarin
Occurrence of anti-RA33 antibody in various types of juvenile idiopathic arthritis Gabor Nagy, Barbara Szasz, Diana Garan, Ibolya Szollosi, Sandor Sipka, Tamas Constantin
MMP-3 is a marker for disease activity in rheumatoid arthritis S. Reuter, T. Matthias
The conversion of QuantiFERON TB Gold test during biological treatment by anti-TNF preparations E. Zanova, D. Kozakova, I. Rybar, I. Solovic, J. Rovensky
Interferon-gamma and QuantiFERON-TB Gold test conversion during biological treatment D. Kozakova, E. Zanova, I. Rybar, I. Solovic, J. Rovensky
Chapter 5 Autoantibodies in Organ Specific Diseases
5.1 Neurological Diseases
New antibodies in multiple sclerosis Bernhard Hemmer
Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis Myrthe Rouwette, Jean-Paul Noben, Jack Van Horssen, Bart Van Wijmeersch, Raymond Hupperts, Peter J. Jongen, Marcel M. Verbeek, Peter P. De Deyn, Piet Stinissenand Veerle Somers
Diagnostic and pathophysiologic relevance of autoantibodies against aquaporin-4 F. Paul, B. Wildemann, S. Jarius
Autoantibodies against the neuronal surface antigen DPPX: markers for an emerging neurological disease entity Bettina Balint, Simon Nagel, Uwe Haberkorn, Christian Probst, Inga-Madeleine Blöcker, Bianca Teegen, Kristin Rentzsch, Ramona Bahtz, Lars Komorowski, Sandra Saschenbrecker, Andreas Kastrup, Martin Kuthe, Hans-Michael Meinck, Winfried Stöcker
Nonradioactive determination of autoantibodies against acetylcholine receptors in myasthenia gravis: A new enzyme-linked immunoassay for manual and automated processing J. Westermann, E. Denczyk, C. Probst, L. Komorowski, W. Schlumberger
Generation of stable HEp-2 cell line M4 expressing human muscle-specific kinase for automatic videoscan-based immunofluorescence diagnostics of Myasthenia gravis S. George, S. Paulick, I. Knütter, N. Röber, R. Hiemann, D. Roggenbuck, K. Conrad and J.-H. Küpper
Clinical validation of a novel immunofluorescence assay for the detection of anti-MuSK antibodies based on MuSK transfected HEp-2 cells Nadja Röber, Silke Weber, Jochen Schäfer, Sandra George, Ilka Knütter, Dirk Roggenbuck, Jan-Heiner Küpper, Karsten Conrad
Pleural mesothelioma and anti-MA2-associated encephalitis Adriano Jiménez-Escrig, Silvia Medina, Ángela Carrasco
What should be the cut-off for VGKC complex antibodies? Sylvie Coito, Réné-Louis Humbel
Multi-center validation study of DNER as the target of anti-PCA-Tr autoantibodies associated with paraneoplastic neurological syndrome Kristin Rentzsch, Inga-Madeleine Blöcker, Bianca Teegen, Winfried Stöcker, Francesc Graus, Véronique Rogemond, Jérome Hônnorat, Esther S. P. Hulsenboom, Peter A. E. Sillevis Smitt, Christian Probst, Lars Komorowski
Multi-parametric recombinant cell-based indirect immunofluorescence assay (RC-IFA) for the determination of autoantibodies associated with paraneoplastic neurological syndromes Inga-Madeleine Blöcker, Christiane Radzimski, Mandy Unger, Linda Döring, Winfried Stöcker, Josep Dalmau, Peter Sillevis Smitt, Lars Komorowski, Christian Probst
5.2 Liver and Gastrointestinal Diseases
Preliminary report: Detection of antibodies against D-3-phosphoglycerate dehydrogenase (PGDH) in autoimmune liver diseases using a line immune assay W. Meyer, C. Probst, L. Komorowski, A. Ott, T. Scheper, W. Schlumberger, W. Stöcker and H. Yan
Can the HEp-2 cell assay replace the indirect immunofluorescence on rat cryostat section for AMA-M2 screening? Kristin Kühnert, Uta Kießling, Teresa Trimpop, Manuela Rejzek, Andrea Thieme, Nadja Röber, Karsten Conrad
Prevalence of anti-nuclear antibodies in patients with primary biliary cirrhosis Ana Kozmar, Ivan Padjen, Miroslav Mayer, Mirna Sentic, Branko Malenica
Evaluation of a high sensitive assay for the diagnosis of celiac disease Lisbeth Witt, Martin Salden, Klas Sjöberg, Fritz Koning and Yngve Sommarin
CytoBead-assay for the simultaneous detection of celiac disease specific antibodies and IgA deficiency Nadja Röber, Kai Grossmann, Ilka Knütter, Rico Hiemann, Mandy Sowa, Martin W. Laass, Karsten Conrad, Dirk Roggenbuck
Pancreatic-specific autoantibodies to glycoprotein 2 in pediatric celiac disease Martin W. Laass, Dirk Roggenbuck, Ursula Range, Nadja Röber, Karsten Conrad
Comparison of two ELISAs for the detection of anti-MZGP2 antibodies as a new serological marker for Crohn`s disease Laura M. Stinton, Gary L. Norman, Zakera Shums, Maria T. Arias-Loste, Marcos Lopez-Hoyos, Michael Mahler
5.3 Endocrine, Kidney and Skin Diseases
Detection of autoimmunity against the insulin-and insulin-like growth factor-1 receptor and their prevalence in humans T. Welsink, C. Schwiebert, W. B. Minich, L. Schomburg
Role of autoantibodies anti zinc transporter protein (anti-ZnT8) in the diagnosis and follow-up of type I diabetes mellitus: an Italian experience S. Zago, M. Fabris, P. Melli, M. Zanatta, T. Basso, A. Comici, E. Carlin, G. Zanette, E. Tonutti, A. Rosolen A. Radice
Serological profile of idiopathic membranous nephropathy cohort Astrid Behnert, Beina Teng, Janina Müller-Deile, Andrej Skoberne, Mario Schiffer, Marvin J. Fritzler
Our experience with anti-phospholipase A2 receptor (PLA2R) indirect immunofluorescence test I. Janatková, M. Hinďoš, Z. Hrušková, B. Svobodová, V. Tesař, K. Malíčková, T. Zima
Evaluation of a new ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy W. Schlumberger, C. Dähnrich, C. Probst, B. Seitz-Polski, V. Esnault, J. F. Wetzels, J. M. Hofstra, E. Hoxha, R. A. Stahl, G. Lambeau, W. Stöcker, L. Komorowski
Detection of anti-phospholipase A2 receptor autoantibodies: A comparison of three different immunoassays Astrid Behnert, Mario Schiffer, Michael Mahler, Marvin J. Fritzler
Anti-M-type Phospholipase A2 Receptor (PLA2r) antibodies in diagnosis and follow-up of idiopathic membranous nephropathy (IMN) S. Glionna, L. Bianchi, B. Trezzi, M. D’Amico, T. Stellato, D. Santoro, R. A. Sinico and A. Radice
The antiphospolipid antibodies in psoriasis patients with metabolic syndrome and non-alcoholic fatty liver disease comorbidities N. Virstyuk, M. Volochynovych, M. Nykyforuk
Development of sensitive and specific assays for serological diagnosis of anti-laminin 332 mucous membrane pemphigoid S. Groth, A. Abadpour, K. Vafia, C. Probst, L. Komorowski, W. Schlumberger, W. Stöcker, D. Zillikens and E. Schmidt
Autoantibodies to Golgi complex and Ro51 protein in non-specific interstitial pneumonia (NSIP): case report and literature review S. Andrejevic, B. Milenkovic, J. Stojsic, R. Stevic, B. Bonaci-Nikolic
Chapter 6 Methodical Aspects and Diagnostic Strategies
6.1 New Concepts and Novel Assays
New Concepts and Approaches to Autoantibody Testing Laura M. Sinton, Marvin J. Fritzler
PR3-ANCA as a promising biomarker for the diagnosis of primary sclerosing cholangitis (PSC) Laura M. Stinton, Chelsea Bentow, Michael Mahler, Gary L. Norman, Bertus Eksteen, Andrew L. Mason, Gilaad G. Kaplan, Bjorn Lindkvist, Angela Cheung, Harry Janssen, Marvin J. Fritzler
Standardization of reference material for autoantibody testing: the state of the art Pier Luigi Meroni, Maria Orietta Borghi
New diagnostics in autoimmunity: a review and our experience Boris Gilburd, Carlo Perricone, Enrica Cipriano, Nancy Agmon-Levin, Yehuda Shoenfeld
Evaluation of a novel sensitive and reliable Lateral Flow Assay (LFA) for the detection of anti-dsDNA antibodies Anti-dsDNA LFA N. Offermann, M. Petschinka and M. Fooke
Microtiter plate-based multiparametric assay for detection of non-organ specific autoantibodies Jana Langer, Erik Höchel, Klemens Löster, Martin Eberhardt, Nadja Röber, Karsten Conrad, Silvia Porstmann, Tomas Porstmann
CytoBead ANCA -a novel indirect immunofluorescence test for the simultaneous detection of anti-neutrophil cytoplasmic antibodies Mandy Sowa, Ilka Knütter, Rico Hiemann, Kai Grossmann, Nadja Röber, Ursula Anderer, Karsten Conrad, Dirk Reinhold, Elena Csernok, Dirk Roggenbuck
Evaluation of ANCA by automated IFA image analysis on NOVA View Carol E. Buchner, Cassandra C. Bryant, Rachel A. Rosenblum, Marlene Gonzalez, Gabriella Lakos
Development of a method for multiplex real-time analysis of enzymatic activity on a microbead-chip Stefan Rödiger, Alexander Böhm, Jörg Nitschke, Luba Stavitskaya, Melanie Gruner, Alena V. Kundzer, Margarita V. Volkova, I. Generalov, Carsten Schmidt, Christian Schröder, Dirk Roggenbuck, Peter Schierack
6.2 Antinuclear Antibodies – Diagnostic Strategies and Novel Developments
CytoBead – A novel platform for antibody multiplex analyses Rico Hiemann, Mandy Sowa, Kai Grossmann, Ilka Knütter, Juliane Scholz, Nadja Röber, Ursula Anderer, Dirk Reinhold, Peter Schierack, Karsten Conrad, Dirk Roggenbuck
Anti-nuclear antibodies: a long way to harmonization Jan Damoiseaux, Nancy Agmon-Levin
Standardization of ANA-HEp-2 immunofluorescence pattern nomenclature Wilson M. Cruvinel, Paulo L. C. Francescantonio, Alessandra Dellavance, Luis E. C. Andrade
ANA measurement by IIF in comparison to other methods in the diagnosis of connective tissue diseases Xavier Bossuyt
Reading and interpretation of ANA immunofluorescence tests: results of a comparative study with six automated systems Nicola Bizzaro, Stefan Platzgummer, Elio Tonutti, Antonio Antico, Danila Bassetti, Danilo Villalta, Fiorenza Pesente, Francesco Cucchiaro, Marilina Tampoia, Renato Tozzoli
Efficient autoantibody titration using indirect immunofluorescence assays (IIFA) Jan Martinek, Ivo Lochman, Alexandra Lochmanová, Vladimír Krauz
Autoimmunity diagnostic strategies (ANA, anti-dsDNA, anti-ENA) in Italian clinical laboratories A. Radice, L. Bianchi, S. Glionna, B. Trezzi
Evaluation of ANA testing results: is there a need for revision of our protocol for antibody specificity testing? Andrea Tesija Kuna, Ines Vukasovic, Nada Vrkic
Automation in ANA HEp-2 cells microscopy: can the machine substitute the human eye? Cristovao Pitangueira Mangueira, Eliane Aparecida Rosseto
HELIOS, a bright future for ANA -automated indirect immunofluorescence (IIF) assay B. Gilburd, N. Agmon-Levin, T. Martins, A. Petzold, T. Matthias and Y. Shoenfeld
Comparability of the AESKUSLIDES ANA-HEp-2 antinuclear antibody (ANA) immunological test system with a commercially available system Torsten Matthias, Sascha Pfeiffer, Trishna Martins, Peter Trinder and Andrea Petzold
92CytoBead ANA -a novel indirect immunofluorescence test for the simultaneous detection of anti-nuclear antibodies Juliane Scholz, Ilka Knütter, Kai Grossmann, Rico Hiemann, Mandy Sowa, Nadja Röber, Karsten Conrad, Peter Schierack, Dirk Roggenbuck
Evaluation of a novel chemiluminescent assay (QUANTA Flash® CTD Screen Plus) for the rapid detection of autoantibodies in systemic autoimmune rheumatic diseases C. Bentow, A. Seaman, A. Swart, A. Shikhman, N. Goodman, M. Mahler
Quantitative results of automated indirect immunofluorescence enable value added reporting for antinuclear antibody testing Sofie Schouwers, Myriam Bonnet, Patrick Verschueren, René Westhovens, Daniel Blockmans, Godelieve Mariën, Xavier Bossuyt
Optimization of the automated HEp-2 cell assay by stepwise improvement of software algorithms Rico Hiemann, Nadja Röber, Dirk Roggenbuck, Karsten Conrad
Autoantibodies to mitotic cells René-Louis Humbel
Anti-nematin antibodies in practice J. Goetz, R. L. Humbel, G. Uettwiller, F. Habersetzer, M. Doffoel
The clinical significance of anti-DFS70 antibodies as part of ANA testing Michael Mahler
Prevalence and clinical associations of anti-DFS70 antibodies in samples with high titer of ANA but without detectable fine-specificity Michael Mahler, Sofie Schouwers, Roger Albesa, Eric Tena, Nathalie Vandeputte, Doreen Dillaerts, X. Bossuyt
LEDGF/DFS70 antibodies and DFS pattern in routine diagnostics Uwe Höpner, Tim Fülling, Uta Kießling, Teresa Trimpop, Manuela Rejzek, Andrea Thieme, Nadja Röber, Karsten Conrad
Longitudinal study of anti-DFS70 antibodies in 5 patients without antinuclear antibody associated autoimmune rheumatic disease Sofie Schouwers, Michael Mahler, Doreen Dilaerts, Nathalie Vandeputte, Xavier Bossuyt
Evaluation of the first dot blot assay for the detection of anti DFS 70 antibodies as part of a 12plex ANA Profile Johannes Schulte-Pelkum, Eric Tena, Alain Vigneron, Nicolas Bodart, Michael Mahler
Novel autoantibodies showing chromatin binding in the HEp-2 cell assay Angelika Lueking, Heike Goehler, Petra Rengers, Martin Gamer, Klaus Marquardt, Petra Budde, Anna Telaar, Daniel Chamrad, Carmen Theek, Karsten Conrad, and Peter Schulz-Knappe