Antithrombotics

Pathophysiological Rationale for Pharmacological Interventions

herausgegeben von A.G. Herman

1. Platelet activation and aggregation: rationale for combining antithrombotic drugs.
2. Role of nitric oxide in endothelial cell - platelet interactions.
3. Platelets and megakaryocytes in vascular disease.
4. Thrombosis in relation to atherosclerosis.
5. Pharmacological inhibition of the ADP-GP IIb/IIIa-fibrinogen pathway of platelet aggregation.
6. Calcium fluxes in platelets and endothelial cells, mechanisms and functional significance.
7. Inhibition of platelet function by cyclic nucleotides and cyclic nucleotide-dependent protein kinases.
8. Pharmacological modification of platelet-derived cyclooxygenase product formation and its consequences for platelet-vessel wall interactions.
9. Antithrombotics and the lipoxygenase pathway.
10. Pathological expressions of platelet-vessel wall interactions: implications of serotonin.
11. The involvement of PAF in thrombotic events.
12. Prostaglandins and -analogs in the treatment of platelet-vessel wall interaction.
13. Adjuvant agents to enhance and sustain reperfusion with t-PA: studies in experimental dog models.
14. Effect of dietary marine lipids on (anti-)thrombotic mechanisms.